HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid → (2S)-3-{2-Chloro-4-[5-(5-diethylaminomethyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid | HCID 67265480 | — |
| Reactant | (R)-3-Chloro-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-5-methyl-benzamidine | HCID 178426667 | — |
| Product | (2S)-3-{2-Chloro-4-[5-(5-diethylaminomethyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-propane-1,2-diol | HCID 66829288 | 40.4% |
Reaction Steps
The title compound (22 mg) is prepared starting from 5-diethylaminomethyl-4-methyl-thiophene-2-carboxylic acid (30 mg, 130 μmol) and (R)-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3-chloro-5-methyl-benzamidine (37 mg, 117 μmol) in analogy to Example 197; LC-MS: tR=0.54 min; [M+1]+=466.05.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148410B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-b76c7f79101a4d38a3af3e5de6567183 |
| Source note | uspto-grants-2012_04 |