Citric Acid → HCID 67265323, compound

Participants

Reaction Steps

2-[4-(3-Oxothian-2-ylidenemethyl)phenyl]propionic acid (80 mg) obtained in Example 4 was dissolved in methanol (1.0 ml), and to the solution was added sodium borohydride (11 mg) under ice cooling. The mixture was stirred at room temperature for 30 minutes. The reaction mixture was acidified with 10% aqueous citric acid, and extracted with chloroform. The organic layer was washed with water and saturated brine, and then dried over sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (24 mg, 30%).

Provenance & Evidence