Hydrogen Bromide → HCID 24782635, compound

Participants

Reaction Steps

Methyl 2-[4-(3-cyano-4-oxothiolan-3-ylmethyl)phenyl]propionate (2.0 g) obtained in Example 6 was dissolved in 1,4-dioxane (14 ml), then, 47% aqueous hydrobromic acid (10.0 ml) was added and stirred overnight at room temperature. The reaction mixture was quenched with water, and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over sodium sulfate. The solvent was evaporated under reduced pressure, and then the residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give the title compound (1.36 g, 78%).

Provenance & Evidence