反应详情

温度

110 °C

2-[4-(3-Cyano-4-oxothiolan-3-ylmethyl)phenyl]propionic acid (1.27 g) obtained in Example 7 was dissolved in 1,4-dioxane (10.0 ml), 30% aqueous sulfuric acid (10.0 ml) was added to the solution and stirred overnight at 110° C. The reaction mixture was quenched with water, and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over sodium sulfate. The solvent was evaporated under reduced pressure, and then the residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give the title compound (550 mg, 50%).

1. customThe reaction mixture was quenched with water
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water and saturated brine
4. dry with materialdried over sodium sulfate
5. customThe solvent was evaporated under reduced pressure
6. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1)