反应详情

2-[4-(4-Oxothiolan-3-ylmethyl)phenyl]propionic acid (300 mg) obtained in Example 8 was dissolved in toluene (3.0 ml), and to the solution was added the Lawesson's reagent (729 mg), and then the reaction mixture was refluxed by heating for 4 hours. After completion of the reaction, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give the title compound (166 mg, 52.4%).

1. temperaturethe reaction mixture was refluxed
2. temperatureby heating for 4 hours
3. customAfter completion of the reaction
4. customthe solvent was evaporated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1)