Magnesium → HCID 59202233, compound

Participants

Reaction Steps

2-[4-(3-Oxothiolan-2-ylidenemethyl)phenyl]propionic acid (500 mg) obtained in Example 14 was dissolved in a mixture of methanol (20 ml)/tetrahydrofuran (10.0 ml)/water (5.0 ml)/acetic acid (1.1 ml), and to the solution was added magnesium (150 mg). The mixture was stirred at room temperature for 2 hours, and then further magnesium (80 mg) was added, and further the solution was stirred for 2 hours. To the reaction mixture was added water and acetic acid, the solution was concentrated under reduced pressure. Saturated brine was added to the residue, and the mixture was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give the title compound (132 mg, 26%).

Provenance & Evidence