Triethylamine → HCID 67265462, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-[5-bromo-4-(3-hydroxythiolan-2-ylidenemethyl)-2-methoxyphenyl]propionate (50 mg) obtained in Example 50 was dissolved in ethylene glycol dimethyl ether (2 ml), and then to the solution was added ammonium formate (25 mg), triethylamine (0.1 ml) and tetrakis(triphenylphosphine)palladium (50 mg). The mixture was stirred overnight at 80° C. in an argon atmosphere. The solvent was evaporated under reduced pressure, and then the residue was purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to give the title compound (30 mg, 72%).

Provenance & Evidence