Hydrochloric Acid → N-[5-(7-Benzyloxy-6-methoxy-quinazolin-4-ylamino)-pyrimidin-2-yl]-benzamide Dihydrochloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-benzyloxy-4-chloro-6-methoxy-quinazoline (760 mg, 2.53 mmol) and N-(5-amino-pyrimidin-2-yl)-benzamide (542 mg, 2.53 mmol) in DMA was added 4N HCl in dioxane (822 μl, 3.29 mmol) and the reaction heated at 50° C. for 4 hours under nitrogen. The reaction was cooled and filtered. The precipitate was washed with Et2O and dried under reduced pressure to provide the title compound as a light tan brown solid (706 mg).

Provenance & Evidence