反应详情

温度

70 °C

To a solution of (S)-2-amino-4-bromo-butyric acid hydrobromide (2 g, 7.6 mmol) in ethanol (10 ml), at 0° C., was added thionyl chloride (1.11 ml, 15.21 mmol). The solution was stirred at 70° C. for 1 hour, cooled and concentrated in vacuo. Heptane added and mixture concentrated under high vac. Ether was added and the precipitate stirred for 1 hr, filter and dried in vacuo to provide (S)-2-amino-4-bromo-butyric acid ethyl ester hydrochloride as an sticky white solid (1.9 g).

1. temperaturecooled
2. concentrationconcentrated in vacuo
3. additionHeptane added
4. concentrationmixture concentrated under high vac
5. additionEther was added
6. stirringthe precipitate stirred for 1 hr
7. filtrationfilter
8. customdried in vacuo