Sodium Hydroxide → HCID 25017921, compound

HRID 1686049Notes

Reaction equation

HRID 1686049 reaction equation
[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][C:26]4([C:29]([O:31]C)=[O:30])[CH2:28][CH2:27]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:33])[NH:6]2.[OH-].[Na+]>CO>[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][C:26]4([C:29]([OH:31])=[O:30])[CH2:28][CH2:27]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:33])[NH:6]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 25018168HCID 25018168, compound

Product 1

HCID 25017921HCID 25017921, compoundYield 51.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of Example 9 (300 mg) was mixed with 15% NaOH (3 eq) in MeOH (15 ml) and refluxed for 30 minutes. The reaction was evaporated and adjusted to PH=6, then filtered to give the titled compound (150 mg). Mass: (M+1), 437

Workup

  1. temperaturerefluxed for 30 minutes
  2. customThe reaction was evaporated
  3. filtrationfiltered

Sources & evidence

ORD record
ord-134f7865f90543b6aec7eae57e0bf1cc
Source dataset
uspto-grants-2012_04
Patent number
US08148532B2

Reaction notes

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