HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanecarboxaldehyde → HCID 25017408, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanecarboxaldehyde | HCID 123114 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Anlotinib | HCID 25017411 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 25017408 | HCID 25017408 | — |
Reaction Steps
The compound of Example 24 (100 mg) was refluxed with cyclopropanecarbaldehyde (2 eq) in EtOH (8 ml) for 4 hours. To the reaction was added NaBH4 (2.2 eq), the reaction was refluxed for 20 minutes and evaporated. The residue was purified with silica gel column to give the titled product (50 mg). Mass: (M+1), 462
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148532B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-075172a312df46d0b9831bcce6e784fd |
| Source note | uspto-grants-2012_04 |