反应详情

To a solution of 2-chloro-3-pyridylmethanol (2.07 g) in 100 mL CH2Cl2 was added imidazole (1.96 g). TBDMSCl (2.39 g) was added in one portion, and the reaction was stirred at room temperature for 23 h, then filtered through a fritted funnel The liquid filtrate was concentrated and purified via flash chromatography to give 3.18 g of 3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloropyridine.

1. filtrationfiltered through a fritted funnel The liquid filtrate
2. concentrationwas concentrated
3. custompurified via flash chromatography