HuagongsheHuagongshe Chemistry Print Report · For research reference only
PyBroP → HCID 67264405, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | PyBroP | HCID 2733179 | — |
| Reactant | 4-(Difluoromethyl)-2-methyl-1,3-thiazole-5-carboxylic acid | HCID 16727056 | — |
| Reactant | HCID 86643790 | HCID 86643790 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 67264405 | HCID 67264405 | 56.4% |
Reaction Steps
A solution of 133 mg of 4-(difluoromethyl)-2-methyl-1,3-thiazole-5-carboxylic acid, 110 mg 5-(trimethylsilyl)pentan-2-amine, 354 mg of PyBroP [bromo-tris-pyrrolidino-phosphonium hexafluorophosphate], and 142 mg N,N′-diisopropylamine in 10 mL acetonitrile was stirred over night at room temperature. Aqueous work-up [extraction with 1.0M NaOH], and silica gel chromatography yielded 130 mg (53%) of a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148538B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-d525e5e97cff48fcba8ffcbae0ab3ef9 |
| Source note | uspto-grants-2012_04 |