Rhodanine → HCID 86627408, compound

HRID 1686143Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([N:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=2)=[CH:11][C:10]=1[CH:24]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:26]=[C:27]1[NH:31][C:30](=[O:32])[CH2:29][S:28]1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([N:21]([CH3:22])[CH3:23])=[CH:19][CH:20]=2)=[CH:11][C:10]=1[CH:24]=[C:29]1[S:28][C:27](=[S:26])[NH:31][C:30]1=[O:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 1201546Rhodanine

HCID 86627409HCID 86627409, compound

Product 1

HCID 86627408HCID 86627408, compoundYield 60.1%

Procedure

4-Benzyloxy-4′ dimethylaminobiphenyl-3-carbaldehyde (0.1 g, 0.302 mmol) obtained in step 2) was reacted with 2-thioxo-thiazolidin-4-one (0.04 g, 0.302 mmol) in the same procedure as in step 2) of Example 1 to afford the object compound (0.081 g, 60%).

Sources & evidence

ORD record: ord-a3d92f75831b4147bf809013d3c9def2
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08148541B2

Reaction notes

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