Sodium Iodide → HCID 86627412, compound

Participants

Reaction Steps

2-(2-Bromobenzyloxy)-4-(2-bromoethoxy)benzaldehyde (100 mg, 0.241 mmol) synthesized in step 3 was dissolved in acetone, and K2CO3 (66.6 mg, 0.482 mmol), NaI (3.6 mg, 0.024 mmol), and morpholine (0.032 ml, 0.362 mmol) were added to the solution, followed by flux with stirring. After stirring for 24 hours, the solution was cooled, filtered, washed with brine, and extracted with CH2Cl2. Then, the extract was dried over anhydrous MgSO4 and filtered and the filtrate was concentrated in a vacuum. The residue was subjected to column chromatography (50% EA/Hx) to afford the object compound (yellowish oil, 52 mg, 51%).

Provenance & Evidence