Potassium Carbonate → HCID 131729541, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(2-bromobenzyloxy)-4-hydroxybenzaldehyde (60 mg, 020 mmol) in DMF (10 ml) were added t-butyl-2-bromoethylcarbamate (43.70 g, 0.20 mmol) and K2CO3 (54.18 mg, 0.39 mmol), followed by stirring at 100° C. for 3 hours. After completion of the reaction, the solution was extracted with a saturated aqueous NH4Cl solution and ethyl acetate. The organic layer was dried over anhydrous MgSO4 and filtered. The filtrate was concentrated in a vacuum. The residue was purified through column chromatography (ethyl acetate/n-hexane=1/9→1/5) to afford the object compound (pale yellowish solid, 69 mg, 79.3%).

Provenance & Evidence