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HRID1686299

反应详情

EQUATION

反应方程式

HRID 1686299 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccccc1CBr
HCID6992

1-(Bromomethyl)-2-methylbenzene

C8H9Br

结构：Cc1noc(C)c1Cn1cc(N2C(=O)CNC2=O)cn1
HCID57422424

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccccc1CN1CC(=O)N(c2cnn(Cc3c(C)noc3C)c2)C1=O
HCID57422442

未命名化合物

收率 21%

PROCEDURE

实验过程

Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 1-(bromomethyl)-2-methylbenzene. Yield: 21%. MS M+H calculated 380.1. found 380.1. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.1 uM.