HCID 57419852, compound → HCID 57944916, compound

Participants

Role	Name	HCID	Charge
Reactant	HCID 57419852	HCID 57419852	—
Reactant	3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione	HCID 57422424	—
Product	HCID 57944916	HCID 57944916	22%

Reaction Steps

Prepared as in example 10-5 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 3-(bromomethyl)-1,5-dimethyl-1H-pyrazole. Yield: 22%. MS M+H calculated 384.1. found 384.1. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.3 uM

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08148544B2
Source dataset	uspto-grants-2012_04
ORD ID	ord-8a1357b30fce4c778dd7cd6ef016501d
Source note	uspto-grants-2012_04