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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1686350생성일: 2026년 10월 25일

1-(2-Bromoethyl)-2-chlorobenzene → 1-(2-chlorophenethyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione

https://huagongshe.com/reaction/1686350

반응식

참여 물질

역할이름HCID투입량
반응물1-(2-Bromoethyl)-2-chlorobenzeneHCID 2756963—
반응물3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dioneHCID 57422424—
생성물1-(2-chlorophenethyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dioneHCID 5794497725%

반응 단계

Prepared as in example 10-52 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 2-chlorophenethyl bromide. Yield: 25%. MS M+H calculated 414.13. found 414.2. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.250M.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08148544B2
출처 데이터셋uspto-grants-2012_04
ORD IDord-4e8b2a5e3b64460fab4e88502b0501dd
출처 메모uspto-grants-2012_04