Nitric Acid → HCID 86643956, compound

Participants

Reaction Steps

An ethanolic solution of nitric acid (0.1 M solution, 6 ml, 0.6 mmol) was added to a stirred 0.1M ethanolic solution of aliskiren base (AKN) (6 ml, 0.6 mmol), and the solution was stirred for an hour at room temperature. Ethanol was evaporated under vacuum at 40° C. to dryness. The solid was suspended in 1 ml of isopropanol. After an hour the suspension became unstirrable and 1 ml of isopropanol was added. The suspension was stirred at room temperature overnight. The solid was filtered and dried at 40° C. under vacuum overnight. The wet and dry samples were analyzed by XRPD.

Provenance & Evidence