Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 2-Chloro-1-fluoro-4-methylsulfonylbenzene | HCID 21340880 | — |
| Reactant | HCID 58785142 | HCID 58785142 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86625033 | HCID 86625033 | 43.6% |
Reaction Steps
The product from step (iv) (4.4 g), 3-chloro-4-fluorophenyl methyl sulfone (4.27 g), cesium carbonate (6.5 g) and NMP (40 ml) were charged to a flask and stirred at 90° C. for 2 h. The reaction was diluted with water, extracted with EtOAc, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by flash column chromatography (eluent 2:1 isohexane/ether) to give the subtitle compound (3.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08148572B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-333ab13e856d456ab3ffae2922ee7345 |
|---|
| Source note | uspto-grants-2012_04 |
|---|
