1-Fluoro-4-(methylsulphonyl)benzene → {4-Chloro-3-[4-(methylsulfonyl)phenoxy]phenyl}acetic acid

HRID 1686380Notes

Reaction equation

HRID 1686380 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[OH:12].[CH3:13][S:14]([C:17]1[CH:22]=[CH:21][C:20](F)=[CH:19][CH:18]=1)(=[O:16])=[O:15]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[O:12][C:20]1[CH:21]=[CH:22][C:17]([S:14]([CH3:13])(=[O:16])=[O:15])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 679941-Fluoro-4-(methylsulphonyl)benzeneHCID 30171834-Chloro-3-hydroxyphenylacetic acid

Product 1

HCID 16124635{4-Chloro-3-[4-(methylsulfonyl)phenoxy]phenyl}acetic acid

Procedure

The title compound was prepared by the method of example 2 step (iii) using the product of example 1 step (iii) and 4-fluorophenyl methyl sulfone.

Sources & evidence

ORD record
ord-9312c29ceb2d4e3faa9198ea60f9c080
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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