HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → Methyl(4-chloro-3-methoxyphenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-3-hydroxyphenylacetic acid | HCID 3017183 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl(4-chloro-3-methoxyphenyl)acetate | HCID 57609448 | — |
Reaction Steps
The product of example 1 step (iii) (1 g), dimethyl sulfate (1 ml), potassium carbonate (1.48 g) and acetone (20 ml) were charged to a flask and heated at reflux for 16 h. The reaction was diluted with water, extracted with EtOAc, dried (MgSO4) and evaporated under reduced pressure to give the subtitle compound (1.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-79a0e8db07cf4083a40355f7741959dd |
| Source note | uspto-grants-2012_04 |