Isobutylamine → HCID 68951925, compound

HRID 1686395Notes

Reaction equation

HRID 1686395 reaction equation
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[Cl:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=1[F:16])[C:10](Cl)=[O:11]>C(Cl)Cl>[Cl:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=1[F:16])[C:10]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:11]

Participants

4

Reactant 2

HCID 6558IsobutylamineHCID 27365483-Chloro-4-fluorobenzoyl Chloride

Product 1

HCID 68951925HCID 68951925, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Isobutyl amine (2 molar equivalent) was added to a solution of 3-chloro-4-fluorobenzoyl chloride (1 g) in DCM (10 ml) and stirred for 2 h. The reaction was diluted with DCM, washed with water, dried (MgSO4) and evaporated under reduced pressure to give a white solid (1.2 g).

Workup

  1. washwashed with water
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-99565143897b4f6ba406bd493bec9828
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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