4-Chloro-3-hydroxyphenylacetic acid → {4-Chloro-3-[2-fluoro-4-(phenylsulfonyl)phenoxy]phenyl}acetic acid

HRID 1686404Notes

Reaction equation

HRID 1686404 reaction equation
[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13](F)=[C:12]([F:17])[CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([OH:28])=[O:27])=[CH:21][C:20]=1[OH:29]>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([OH:28])=[O:27])=[CH:21][C:20]=1[O:29][C:13]1[CH:14]=[CH:15][C:10]([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])=[CH:11][C:12]=1[F:17]

Participants

3

Reactant 2

HCID 30171834-Chloro-3-hydroxyphenylacetic acidHCID 269861771,2-Difluoro-4-phenylsulfonylbenzene

Product 1

HCID 57791953{4-Chloro-3-[2-fluoro-4-(phenylsulfonyl)phenoxy]phenyl}acetic acid

Procedure

The title compound was prepared by the method of example 2 step (iii) using the product of step (i) and the product of example 1 step (iii).

Sources & evidence

ORD record
ord-775d55721c04413e9490448a4a3df3fa
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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