2-Chloro-1-fluoro-4-methylsulfonylbenzene → [3-[2-Chloro-4-(methylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]acetic acid

HRID 1686406Notes

Reaction equation

HRID 1686406 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH3:16][S:17]([C:20]1[CH:25]=[CH:24][C:23](F)=[C:22]([Cl:27])[CH:21]=1)(=[O:19])=[O:18]>>[Cl:27][C:22]1[CH:21]=[C:20]([S:17]([CH3:16])(=[O:19])=[O:18])[CH:25]=[CH:24][C:23]=1[O:1][C:2]1[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 213408802-Chloro-1-fluoro-4-methylsulfonylbenzeneHCID 690656243-Hydroxy-5-(trifluoromethyl)phenylacetic acid

Product 1

HCID 16123103[3-[2-Chloro-4-(methylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]acetic acid

Procedure

The title compound was prepared by the method of example 2 step (iii) using the product of step (iv) and 3-chloro-4-fluorophenyl methyl sulfone.

Sources & evidence

ORD record
ord-f18b7c862d664d6d89558d4e9e4a3bdd
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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