2-(3-Chloro-5-hydroxyphenyl)acetic acid → (3-Chloro-5-{2-chloro-4-[(4-fluorobenzyl)sulfonyl]phenoxy}phenyl)acetic acid

HRID 1686414Notes

Reaction equation

HRID 1686414 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([OH:8])[CH:7]=1.[Cl:13][C:14]1[CH:19]=[C:18]([S:20]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)(=[O:22])=[O:21])[CH:17]=[CH:16][C:15]=1F>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([O:8][C:15]2[CH:16]=[CH:17][C:18]([S:20]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)(=[O:21])=[O:22])=[CH:19][C:14]=2[Cl:13])[CH:7]=1

Participants

3

Reactant 2

HCID 596446192-(3-Chloro-5-hydroxyphenyl)acetic acidHCID 689534292-Chloro-1-fluoro-4-[(4-fluorobenzyl)sulfonyl]benzene

Product 1

HCID 16123212(3-Chloro-5-{2-chloro-4-[(4-fluorobenzyl)sulfonyl]phenoxy}phenyl)acetic acid

Procedure

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 18 step (iv) and the product from step (i).

Sources & evidence

ORD record
ord-a9bd247db07b44f6a32d11507384fd1d
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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