3-Chloro-4-fluorophenyl phenyl sulfone → [3-[2-Chloro-4-(phenylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]acetic acid

HRID 1686416Notes

Reaction equation

HRID 1686416 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[C:16]1([S:22]([C:25]2[CH:30]=[CH:29][C:28](F)=[C:27]([Cl:32])[CH:26]=2)(=[O:24])=[O:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[Cl:32][C:27]1[CH:26]=[C:25]([S:22]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)(=[O:23])=[O:24])[CH:30]=[CH:29][C:28]=1[O:1][C:2]1[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 689525093-Chloro-4-fluorophenyl phenyl sulfoneHCID 690656243-Hydroxy-5-(trifluoromethyl)phenylacetic acid

Product 1

HCID 16123316[3-[2-Chloro-4-(phenylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]acetic acid

Procedure

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 25 step (iv) and the product from example 29 step (i).

Sources & evidence

ORD record
ord-3f33d7237d3e484cb7bf1a12359fb0c8
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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