2-Chloro-4-(ethylsulfonyl)-1-fluorobenzene → 2-[3-[2-Chloro-4-(ethylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]propanoic acid

HRID 1686425Notes

Reaction equation

HRID 1686425 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:17]([S:19]([C:22]1[CH:27]=[CH:26][C:25](F)=[C:24]([Cl:29])[CH:23]=1)(=[O:21])=[O:20])[CH3:18]>>[Cl:29][C:24]1[CH:23]=[C:22]([S:19]([CH2:17][CH3:18])(=[O:21])=[O:20])[CH:27]=[CH:26][C:25]=1[O:1][C:2]1[CH:3]=[C:4]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 579047252-Chloro-4-(ethylsulfonyl)-1-fluorobenzeneHCID 667340972-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid

Product 1

HCID 161235362-[3-[2-Chloro-4-(ethylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]propanoic acid

Procedure

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 50 step (iii) and the product from example 3 step (i).

Sources & evidence

ORD record
ord-5c404b61581f4ecba69e4ac5e2eb0367
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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