2-(3-Chloro-5-hydroxyphenyl)acetic acid → (3-Chloro-5-{4-[(4-chlorobenzyl)sulfonyl]-2-fluorophenoxy}phenyl)acetic acid

HRID 1686429Notes

Reaction equation

HRID 1686429 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([OH:8])[CH:7]=1.[Cl:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][S:19]([C:22]2[CH:27]=[CH:26][C:25](F)=[C:24]([F:29])[CH:23]=2)(=[O:21])=[O:20])=[CH:16][CH:15]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([O:8][C:25]2[CH:26]=[CH:27][C:22]([S:19]([CH2:18][C:17]3[CH:30]=[CH:31][C:14]([Cl:13])=[CH:15][CH:16]=3)(=[O:20])=[O:21])=[CH:23][C:24]=2[F:29])[CH:7]=1

Participants

3

Reactant 2

HCID 596446192-(3-Chloro-5-hydroxyphenyl)acetic acidHCID 689551304-[(4-Chlorobenzyl)sulfonyl]-1,2-difluorobenzene

Product 1

HCID 16123534(3-Chloro-5-{4-[(4-chlorobenzyl)sulfonyl]-2-fluorophenoxy}phenyl)acetic acid

Procedure

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 18 step (iv) and the product from step (i).

Sources & evidence

ORD record
ord-0aa811b901d446f39b407f4454df4930
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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