HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-5-fluorobenzonitrile → 3-Bromo-5-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-5-fluorobenzonitrile | HCID 2783330 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Product | 3-Bromo-5-methoxybenzonitrile | HCID 25067362 | 96.2% |
Reaction Steps
Sodium methoxide (2.02 g) was added to a stirred solution of 3-fluoro-5-bromobenzonitrile (5.0 g) in DMPU (20 ml) and stirred at RT for 2 h. The reaction was diluted with water and the resulting solid formed was filtered and washed with water, then dried in vacuo to give the subtitle compound (5.10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-e8f646b8850343f7a8c326f87b4a52e7 |
| Source note | uspto-grants-2012_04 |