HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-Bromo-5-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Bromo-5-methoxybenzonitrile | HCID 25067362 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Bromo-5-methoxybenzoic acid | HCID 4060048 | — |
Reaction Steps
The product from step (i) (5.10 g) was dissolved in methanol (20 ml) and 6N NaOH (20 ml) and heated to reflux for 6 h. The mixture was diluted with 2M HCl, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to give a white solid (5.10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-c6caa1c3ad4847c4967ede8fa493678d |
| Source note | uspto-grants-2012_04 |