HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 3-bromo-5-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 2-(3-Bromo-5-hydroxyphenyl)acetic acid | HCID 66734166 | — |
| Product | Methyl 3-bromo-5-hydroxybenzoate | HCID 53216607 | — |
Reaction Steps
The product from example 55 step (v) (3.24 g) was added to a preformed solution of methanol (200 ml) and acetyl chloride (20 ml) and stirred at RT overnight. The mixture was evaporated under reduced pressure to give an oil. The oil was purified by flash column chromatography (eluent 1:1 ether/isohexane) to give the subtitle compound (3.16 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a0860aa83c5c4042aecf3d2a0a64eb5e |
| Source note | uspto-grants-2012_04 |