HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-[(3-Chloro-4-fluorophenyl)sulfonyl]morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 3-Chloro-4-fluorobenzenesulphonyl chloride | HCID 145222 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[(3-Chloro-4-fluorophenyl)sulfonyl]morpholine | HCID 697826 | — |
Reaction Steps
4-fluoro-3-chlorobenzenesulphonyl chloride (0.9 g) was stirred in dry DCM (10 ml) and morpholine (0.69 ml) added. The mixture was allowed to stir at RT for 1 h and then quenched with water, extracted with DCM, dried (MgSO4) and evaporated under reduced pressure to give a white solid (1.10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-9630a25f50aa454dade9a9dfd6f7ac7e |
| Source note | uspto-grants-2012_04 |