(3-Chloro-4-fluorophenyl)(phenyl)methanone → [3-(4-Benzoyl-2-chlorophenoxy)-5-(trifluoromethyl)phenyl]acetic acid

HRID 1686448Notes

Reaction equation

HRID 1686448 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl:16][C:17]1[CH:18]=[C:19]([C:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:25])[CH:20]=[CH:21][C:22]=1F>>[C:24]([C:19]1[CH:20]=[CH:21][C:22]([O:1][C:2]2[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=2)=[C:17]([Cl:16])[CH:18]=1)(=[O:25])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 15023215(3-Chloro-4-fluorophenyl)(phenyl)methanoneHCID 690656243-Hydroxy-5-(trifluoromethyl)phenylacetic acid

Product 1

HCID 16123764[3-(4-Benzoyl-2-chlorophenoxy)-5-(trifluoromethyl)phenyl]acetic acid

Procedure

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 25 step (iv) and the product from step (i).

Sources & evidence

ORD record
ord-c15ffc05120943818e306b490d4fc8d5
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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