1,2-Difluoro-4-phenylsulfonylbenzene → {3-Bromo-5-[2-fluoro-4-(phenylsulfonyl)phenoxy]phenyl}acetic acid

HRID 1686450Notes

Reaction equation

HRID 1686450 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([OH:8])[CH:7]=1.[C:13]1([S:19]([C:22]2[CH:27]=[CH:26][C:25](F)=[C:24]([F:29])[CH:23]=2)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([O:8][C:25]2[CH:26]=[CH:27][C:22]([S:19]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)(=[O:21])=[O:20])=[CH:23][C:24]=2[F:29])[CH:7]=1

Participants

3

Reactant 2

HCID 269861771,2-Difluoro-4-phenylsulfonylbenzeneHCID 667341662-(3-Bromo-5-hydroxyphenyl)acetic acid

Product 1

HCID 16123766{3-Bromo-5-[2-fluoro-4-(phenylsulfonyl)phenoxy]phenyl}acetic acid

Procedure

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 55 step (v) and the product from example 24 step (i).

Sources & evidence

ORD record
ord-9e7381f81f254fbd8be8e3fed5da906d
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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