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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1686451Generated: November 1, 2026

1,2-Difluoro-4-[(4-fluorophenyl)sulfonyl]benzene → [3-{2-Fluoro-4-[(4-fluorophenyl)sulfonyl]phenoxy}-5-(trifluoromethyl)phenyl]acetic acid

https://huagongshe.com/reaction/1686451

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-Difluoro-4-[(4-fluorophenyl)sulfonyl]benzeneHCID 68948821—
Reactant3-Hydroxy-5-(trifluoromethyl)phenylacetic acidHCID 69065624—
Product[3-{2-Fluoro-4-[(4-fluorophenyl)sulfonyl]phenoxy}-5-(trifluoromethyl)phenyl]acetic acidHCID 16123767—

Reaction Steps

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 25 step (iv) and the product from step (i).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08148572B2
Source datasetuspto-grants-2012_04
ORD IDord-070f14ca65694d739d8b74cdd443a331
Source noteuspto-grants-2012_04