Benzene → Phenyl(2,4,6-trifluorophenyl)methanone

HRID 1686458Notes

Reaction equation

HRID 1686458 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([F:12])[C:3]=1[C:4](Cl)=[O:5].[CH:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>O>[C:13]1([C:4]([C:3]2[C:2]([F:1])=[CH:10][C:9]([F:11])=[CH:8][C:7]=2[F:12])=[O:5])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 241BenzeneHCID 1448952,4,6-Trifluorobenzoyl chloride

Product 1

HCID 2777009Phenyl(2,4,6-trifluorophenyl)methanone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2,4,6-trifluorobenzoyl chloride (5.0 g), benzene (5 ml) and ferric chloride (1.39 g) were heated at 80° C. for 16 h, then allowed to cool to room temperature. The reaction mixture was diluted with water, extracted with ethyl acetate (×2) and the combined organic extracts washed with brine, dried (MgSO4) and evaporated under reduced pressure (5.80 g).

Workup

  1. extractionextracted with ethyl acetate (×2)
  2. washthe combined organic extracts washed with brine
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure (5.80 g)

Sources & evidence

ORD record
ord-d737ebcb26e74a079cebfd6ae9304fdb
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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