反应详情

The product from example 55 step (vi) (0.45 g), 2-pyridyl zinc bromide (0.89 ml) and bisdiphenylphosphinoferrocene palladium (II) (0.04 g) in dry dioxane (20 ml) were heated to 90° C. for 20 h. Mixture diluted with water, extracted with DCM, dried (MgSO4) and evaporated under reduced pressure to an oil, which was purified by RPHPLC to give a white solid (3 mg).

1. extractionextracted with DCM
2. dry with materialdried (MgSO4)
3. customevaporated under reduced pressure to an oil, which
4. customwas purified by RPHPLC