Hydrochloric Acid → HCID 131729542, compound

Participants

Reaction Steps

Methyl-3,5-dihydroxyphenyl acetate (0.20 g), cesium carbonate (1.08 g) and the product from example 3 step (i) in dry NMP were heated at 50° C. for 4 h. 2M HCl was added and extracted with ethyl acetate. The organics were dried (MgSO4) and evaporated under reduced pressure to a brown oil, which was purified by flash column chromatography (eluent 1:1 ethyl acetate/isohexane) to give a mixture of the mono- and bis-coupled products used in the next step without further purification.

Provenance & Evidence