HCID 67264557, compound → HCID 67264564, compound

HRID 1687277Notes

Reaction equation

HRID 1687277 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[C:14]([N:21]3[CH:25]=[CH:24][CH:23]=[N:22]3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]>[Pd].CCO>[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([N:21]3[CH:25]=[CH:24][CH:23]=[N:22]3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 67264557HCID 67264557, compound

Product 1

HCID 67264564HCID 67264564, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-(4-Nitro-3-pyrazol-1-yl-phenyl)-piperidine-4-carboxylic acid ethyl ester was treated under standard hydrogenation conditions (H2, EtOH, 10% Pd/C) to yield desired 1-(4-Amino-3-pyrazol-1-yl-phenyl)-piperidine-4-carboxylic acid ethyl ester as a glass, which was used for the subsequent reaction without further purification; TLC: 1:1 EtOAc/Hexane Rf 0.5, homogeneous; LC/MS (m/e) 315.28 (M+H).

Sources & evidence

ORD record
ord-abc6714c40dc4e73886fc63e64b91973
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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