HCID 67264542, compound → HCID 67264157, compound

HRID 1687361Notes

Reaction equation

HRID 1687361 reaction equation
[NH2:1][C:2]1[C:3]([O:18][CH3:19])=[CH:4][C:5]2[CH2:11][N:10]([CH2:12][CH3:13])[CH2:9][C:8](=[O:14])[N:7]([CH2:15][CH3:16])[C:6]=2[CH:17]=1.Cl[C:21]1[N:26]=[C:25]([NH:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][C:29]=2[N:36]2[CH:40]=[CH:39][CH:38]=[N:37]2)[C:24]([Cl:41])=[CH:23][N:22]=1>>[Cl:41][C:24]1[C:25]([NH:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][C:29]=2[N:36]2[CH:40]=[CH:39][CH:38]=[N:37]2)=[N:26][C:21]([NH:1][C:2]2[C:3]([O:18][CH3:19])=[CH:4][C:5]3[CH2:11][N:10]([CH2:12][CH3:13])[CH2:9][C:8](=[O:14])[N:7]([CH2:15][CH3:16])[C:6]=3[CH:17]=2)=[N:22][CH:23]=1

Participants

3

Reactant 2

HCID 67264542HCID 67264542, compoundHCID 86633898HCID 86633898, compound

Product 1

HCID 67264157HCID 67264157, compound

Procedure

The title compound was prepared from 8-Amino-1,4-diethyl-7-methoxy-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-one and (2,5-Dichloro-pyrimidin-4-yl)-(4-methoxy-2-pyrazol-1-yl-phenyl)-amine in an analogous manner to example 730 (0.044 g, 36%). Mp 97-100° C. LCMS (m/e) 563 (M); 1H-NMR (DMSO, 400 MHz) δ 9.85 (s, 1H), 8.24 (S, 1H), 8.12 (s, 1H), 7.97-7.95 (d, 1H, J=8.84 Hz), 7.90 (s, 2H), 7.82 (s, 1H), 7.16 (s, 1H), 7.04 (s, 1H), 6.83-6.81 (d, 1H, J=8.59 Hz), 6.53 (s, 1H), 3.85 (s, 3H), 3.81 (s, 3H), 3.60-3.50 (m, 1H), 3.49 (s, 2H), 2.95 (s, 2H), 1.10-1.00 (t, 3H, J=7.32 Hz), 0.93-0.83 (t, 3H, J=6.82 Hz).

Sources & evidence

ORD record
ord-167fc30fea2543338d21a93ce0aba2f0
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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