HCID 67263990, compound → HCID 66830153, compound

HRID 1687439Notes

Reaction equation

HRID 1687439 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH2:21])=[CH:5][C:6]2[CH2:12][CH2:11][N:10]([CH:13]([CH2:17][O:18][CH3:19])[CH2:14][O:15][CH3:16])[CH2:9][CH2:8][C:7]=2[CH:20]=1.Cl[C:23]1[N:28]=[C:27]([NH:29][C:30]2([CH2:36][C:37]([NH2:39])=[O:38])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[C:26]([Cl:40])=[CH:25][N:24]=1>>[Cl:40][C:26]1[C:27]([NH:29][C:30]2([CH2:36][C:37]([NH2:39])=[O:38])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)=[N:28][C:23]([NH:21][C:4]2[C:3]([O:2][CH3:1])=[CH:20][C:7]3[CH2:8][CH2:9][N:10]([CH:13]([CH2:14][O:15][CH3:16])[CH2:17][O:18][CH3:19])[CH2:11][CH2:12][C:6]=3[CH:5]=2)=[N:24][CH:25]=1

Participants

3

Reactant 2

HCID 67263990HCID 67263990, compoundHCID 866339402-[1-(2,5-Dichloro-pyrimidin-4-ylamino)-cyclohexyl]-acetamide

Product 1

HCID 66830153HCID 66830153, compound

Procedure

The title compound was prepared from 8-Methoxy-3-(2-methoxy-1-methoxymethyl-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine and 2-[1-(2,5-Dichloro-pyrimidin-4-ylamino)-cyclohexyl]-acetamide in an analogous manner to Example 61e. Product isolated as a pale yellow foam (0.064 g, 49%). MP: 71-83° C. 1H NMR (400 MHz, CDCl3, δ, ppm): 7.92 (s, 1H), 7.84 (s, 1H), 7.14 (s, 1H), 6.64 (s, 1H), 5.40 (br s, 1H), 5.24 (s, 1H), 5.05 (br s, 1H), 3.85 (s, 3H), 3.57-3.51 (m, 2H), 3.47-3.41 (m, 2H), 3.32 (s, 6H), 3.06-2.98 (m, 1H), 2.90 (s, 2H), 2.87-2.77 (m, 8H), 2.37-2.29 (m, 2H), 1.71-1.29 (m, 8H). MS: 561.29 (MH)+.

Sources & evidence

ORD record
ord-9f09d11fa24b4dca86a444470634c05d
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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