HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitroanthranilic acid → 4-Nitro-isatoic anhydride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitroanthranilic acid | HCID 12076 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Nitro-isatoic anhydride | HCID 282089 | 99.8% |
Reaction Steps
2-Amino-4-nitro-benzoic acid (1.00 g, 0.00549 mol) was dissolved in THF. Triphosgene (1.63 g, 0.00549 mol) was dissolved in THF and added. The reaction mixture was stirred at rt for 2 h, concentrated, triturated with H2O, filtered, and taken up in acetone to afford a pale yellow solid (1.14 g, 99.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148391B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6b7d6ed0e9df48f193ae327d1ee67321 |
| Source note | uspto-grants-2012_04 |