HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1687595Generated: November 1, 2026
Acetone → (2-Amino-3-methyl-phenoxy)-acetonitrile
https://huagongshe.com/reaction/1687595
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-m-cresol | HCID 3014138 | — |
| Product | (2-Amino-3-methyl-phenoxy)-acetonitrile | HCID 43438079 | 51% |
Reaction Steps
Into a 1-Neck round-bottom flask was added 2-Amino-3-methyl-phenol (1.00 g, 0.00812 mol), Chloroacetonitrile (0.617 mL, 0.00974 mol), K2CO3 (1.35 g, 9.7 mmol), and Acetone (15 mL, 0.20 mol). The reaction mixture was heated at 50° C. for 4 hr, filtered and concentrated to afford title product (670 mg, 51%) LCMS 163 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08148391B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-1bababa31e884d1e9eedca0813346a54 |
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| Source note | uspto-grants-2012_04 |
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