Ethanol → HCID 62691367, compound

HRID 1687602Notes

Reaction equation

HRID 1687602 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N+:9]([O-:11])=[O:10].C(O)C.[CH3:15][CH:16]([S-:18])[CH3:17].[Na+]>>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([S:18][CH:16]([CH3:17])[CH3:15])[C:3]=1[N+:9]([O-:11])=[O:10]

Participants

4

Reactant 3

HCID 702EthanolHCID 879221,3-Difluoro-2-nitrobenzeneHCID 3470666Sodium 2-propanethiolate

Product 1

HCID 62691367HCID 62691367, compound

Procedure

1,3-Difluoro-2-nitro-benzene (5.00 g, 31.4 mmol) was stirred in Ethanol (25 mL, 430 mmol) and treated with sodium 2-propanethiolate (3.08 g, 31.4 mmol) in several portions over 5 min. The reaction mixture was stirred at rt for 30 mins, was concentrated under reduced pressure, diluted with water, and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure to afford a yellow oil.

Workup

  1. concentrationwas concentrated under reduced pressure
  2. additiondiluted with water
  3. extractionextracted with CH2Cl2
  4. dry with materialThe organic layer was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customto afford a yellow oil

Sources & evidence

ORD record
ord-0ab02c228301458bab86f920bb4766f4
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

Loading…