Dichloromethane → HCID 67263440, compound

HRID 1687626Notes

Reaction equation

HRID 1687626 reaction equation
P(Cl)(Cl)(Cl)(Cl)Cl.[N+:7]([C:10]1[CH:20]=[CH:19][C:13]([O:14][CH2:15][C:16](O)=[O:17])=[C:12]([N:21]2[CH:25]=[CH:24][CH:23]=[CH:22]2)[CH:11]=1)([O-:9])=[O:8].C(Cl)Cl.[OH-].[Na+]>>[N+:7]([C:10]1[CH:20]=[CH:19][C:13]2[O:14][CH2:15][C:16](=[O:17])[C:25]3[N:21]([CH:22]=[CH:23][CH:24]=3)[C:12]=2[CH:11]=1)([O-:9])=[O:8]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 14798Sodium HydroxideHCID 24819Phosphorus pentachlorideHCID 67264114HCID 67264114, compound

Product 1

HCID 67263440HCID 67263440, compound

Procedure

PCl5 (1.30 g, 6.25 mmol) was added slowly to (4-Nitro-2-pyrrol-1-yl-phenoxy)-acetic acid (1.5 g, 5.7 m mol) in CH2Cl2 (40 mL, 0.6 mol) and the reaction mixture was stirred at rt for 16 h. The reaction mixture was poured onto crushed ice, basified with 1 N NaOH, and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure. LCMS 245.10 (M+H).

Workup

  1. additionThe reaction mixture was poured
  2. customonto crushed ice
  3. extractionextracted with CH2Cl2
  4. dry with materialThe organic layer was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-705620ced206497a99c6998a1e298439
Source dataset
uspto-grants-2012_04
Patent number
US08148391B2

Reaction notes

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