HCID 86634047, compound → HCID 86634048, compound

Participants

Reaction Steps

Following an anaologous procedure analogous to Example 1451, 8-amino-7-methoxy-5,5-dimethyl-4-(2,2,2-trifluoro-acetyl)-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-one was converted to N-((1R,2R)-2-{5-Chloro-2-[7-methoxy-5,5-dimethyl-2-oxo-4-(2,2,2-trifluoro-acetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-ylamino]pyrimidin-4-ylamino}-cyclohexyl)-methanesulfonamide TFA salt (7 mg, 4%). 1H-NMR (CDCl3, 400 MHz): δ 9.00 (bs, 1H), 8.25 (s, 1H), 7.92 (s, 1H), 7.32 (bs, 1H), 6.71 (s, 1H), 650 (bs, 1H), 4.17-4.40 (m, 2H), 3.88-4.10 (m, 1H), 3.74 (s, 3H), 3.50 (q, 2H), 3.25-3.43 (m, 1H), 3.06 (s, 3H), 2.03-2.23 (m, 2H), 1.90 (s, 1H), 1.71 (s, 3H), 1.40-1.70 (m, 2H), 0.90-1.40 (complex multiplex m, 4H). LC/MS (ESI+) 634.13 (M+H).

Provenance & Evidence