HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 2,5-Dichloro-4-nitro-thiophene-3-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | n-Methyl-(2,5-dichlorothiophen-3-yl)carboxamide | HCID 23434132 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2,5-Dichloro-4-nitro-thiophene-3-carboxylic acid methylamide | HCID 67264312 | — |
Reaction Steps
An ice-cold mixture of 2,5-dichloro-thiophene-3-carboxylic acid methylamide (475 mg) in H2SO4 (20 mL, 95-98%) was treated with fuming HNO3 (25 mL). The mixture was stirred for 1 hour and slowly poured onto ice, extracted with ethyl acetate three times, and dried over sodium sulfate. Filtration and concentration provided 2,5-dichloro-4-nitro-thiophene-3-carboxylic acid methylamide (565 mg): 1H NMR (300 MHz, CDCl3) δ 6.0 (bs, 1H), 3.0 (d, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148391B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-69ac62f4083d480d9dda50cbbee2f074 |
| Source note | uspto-grants-2012_04 |