HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(Pyridazin-3-yl)cyclopropanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 1-(pyridazin-3-yl)cyclopropylcarbamate | HCID 67291864 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(Pyridazin-3-yl)cyclopropanamine hydrochloride | HCID 67291480 | — |
Reaction Steps
To a solution of tert-butyl 1-(pyridazin-3-yl)cyclopropylcarbamate (0.3 g) in THF (3 ml) at 0° C. was added HCl in dioxane (5 ml) and the mixture stirred at r.t. for 3 hr. The reaction mixture was concentrated, and the crude product was taken for the next coupling reaction. Yield: 0.21 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148382B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-56c22a84996d42688b5e9569c8f8de3a |
| Source note | uspto-grants-2012_04 |